psilocybin

Psilocybin

  1. Nichols, D.E., and Frescas, S. reported improved methods for synthesizing psilocybin and a simple approach for creating the O‑acetyl prodrug of psilocin. Synthesis, 6, 935–938 (1999).
  2. Glatfelter, G.C., Pottie, E., Partilla, J.S., and colleagues examined how structural differences in psilocybin, baeocystin, aeruginascin, and related compounds influence their effects in mice. ACS Pharmacology & Translational Science, 5(11), 1181–1196 (2022).
Product Citations
  • Kato, K., Kleinhenz, J.M., Shin, Y.-J., and co-authors found that psilocybin treatment can extend cellular lifespan and improve survival in aged mice. NPJ Aging, 11(1), 55 (2025).
  • Sekssaoui, M., Bockaert, J., Marin, P., and colleagues explored antidepressant‑like effects of psychedelics in a chronic despair mouse model, questioning whether the 5‑HT2A receptor is the sole mechanism involved. Neuropsychopharmacology, 49(4), 747–756 (2024).
  • Glatfelter, G.C., Pottie, E., Partilla, J.S., and co-authors analyzed structure–activity relationships for psilocybin, baeocystin, aeruginascin, and similar compounds to understand their pharmacological effects in mice. ACS Pharmacology & Translational Science, 5(11), 1181–1196 (2022).
  • Hesselgrave, N., Troppoli, T.A., Wulff, A.B., and colleagues showed that psilocybin’s antidepressant‑like behavioral and synaptic effects in mice occur independently of 5‑HT2R activation. Proceedings of the National Academy of Sciences USA, 118(17), e2022489118 (2021).
Synonyms
Synonyms
  • 4-hydroxy-N,N-Dimethyltryptamine
  • 4-hydroxy DMT
  • Psilocyn
Technical Information
Formal Name                  |     3-[2-(dimethylamino)ethyl]-1H-indol-4-ol
 
CAS Number                   |    520-53-6
 
Molecular Formula         |      C12H16N2O
 
Formula Weight               |    204.3
Purity                                 |    ≥95%
 
Formulation        |  A crystalline solid
 
Solubility(Learn about Variance   in Solubility)       |DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
 
λmax                |  223 nm
 
SMILES       |    OC1=CC=CC2=C1C(CCN(C)C)=CN2
 

InChi Code  | InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3

InChi Key
 
 
 
SPCIYGNTAMCTRO-UHFFFAOYSA-N
 
Regulatory Information
DEA Schedule
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Shipping & Storage Information  
      Storage    |   -20°C
     Shipping   |    Wet ice in continental US; may vary elsewhere
     
 
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